Xymogen’s Regenemax-Plus

Clinical Applications
» Reduces Fine Lines and Wrinkles*
» Thickens and Strengthens Hair*
» Strengthens Nails*
» Supports Healthy Bone Mineral Density*
» Supports Bone Flexibility*
» Promotes Connective Tissue Formation for Healthy Joints*

RegeneMax® Plus features clinically tested ch-OSA® (choline-stabilized orthosilicic acid) complemented with biotin. ch-OSA naturally helps nourish your body’s beauty proteins by supporting and activating enzymes used by
collagen-generating cells to make collagen. Regular orthosilicic acid (OSA) has to be stabilized to avoid polymerization, a process that decreases bioavailability.

ch-OSA’s patented choline-stabilization technology prevents polymers from
forming and ensures OSA’s optimal absorption. By combining ch-OSA with biotin, RegeneMax Plus offers an even greater level of beauty support.*

Where to Buy Xymogen? To ORDER RegeneMax® and other Xymogen products securely and directly from Xymogen:

Looking for Xymogen Products? Xymogen products can only be ordered through a licensed health care provider, like Lifespark.  .

  1. Click on the following link for Lifespark/Horvath. Set up your Xymogen account on Wholescripts. Allow a confirmation email from Wholescripts.  -> https://www.wholescripts.com/register/lifespark
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Discussion

Silicon and Choline-Stabilized Orthosilicic Acid
Silicon is a ubiquitous element present in various tissues of the human body. It performs an important role in connective tissue health, especially in the formation of the organic matrix (e.g., collagen and glycosaminoglycan
formation).[1] Cereal/grain-based products and vegetables are the main dietary sources of silicon, but modern processing is likely to reduce intake from these sources. Soluble silicon is found as orthosilicic acid (OSA) in beverages and water.[2] Because regular orthosilicic acid is highly unstable, leading it to form polymers, and because the polymers are too large for the human body to absorb, RegeneMax Plus features patented “choline stabilization” technology. This stabilization prevents polymers from forming, ensuring optimal
absorption of orthosilicic acid. Choline-stabilized orthosilicic acid (ch-OSA®) is a bioavailable form of silicon that has been found to increase the hydroxyproline concentration in the dermis of animals.[2] Furthermore, the ch-OSA in
RegeneMax Plus is clinically proven for your assurance.*[2-4]

“Beauty Proteins” and Orthosilicic Acid
ch-OSA helps naturally nourish the body’s beauty proteins: collagen, elastin, and keratin. Collagen is the body’s main structural protein. It makes up 70% of skin and gives skin its strength and elasticity. It forms 30% of bone to give bones the flexibility they need to withstand impact. Additionally, the collagen fibers in bone
are the binding sites for calcium and other bone minerals.[5] Collagen is also the major component of fascia, cartilage, ligaments, and tendons. Unfortunately, collagen production begins decreasing at age 18. By the age of 40, the decrease is about 1% per year.[6] For women, the decline equates to a loss of 7% of skin thickness every 10 years. Following menopause, the decline in thickness accelerates to as much as 1.13% annually, while skin elasticity degrades 0.55% per year.[7] Adequate collagen production correlates with healthy bones and
strong hair and nails.*[6-8]

For years, OSA was the focus of intense research because it was viewed as a potential collagen generator. As a result of that research, the molecular complex known ch-OSA was created. Choline not only has the positively charged nitrogen atom that forms the vital bond with OSA, but according to leading collagen researchers, choline transports the orthosilicic acid into target cells where it activates the pathways involved in collagen production. Clinical trials also suggest that beyond its ability to generate collagen, ch-OSA promotes
keratin and elastin formation—two proteins that assist in skin elasticity and hair
tensile strength.*[2-4]

ch-OSA Clinical Studies
In a 20-week, randomized, double-blind, placebo-controlled study of 50 women with photo-damaged facial skin, oral intake of 10 mg/d silicon as ch-OSA resulted in significantly improved skin visco-elastic properties and a 19%
reduction in roughness with a 30% reduction in micro-wrinkle depth (measured as maximum roughness) compared to placebo.[2] In the same clinical trial, the women’s hair and nails showed significant improvements in strength.
Furthermore, serum silicon was significantly higher (+72%) in subjects after 20 weeks of supplementation with ch-OSA compared to the placebo group. In a nine-month, randomized, double-blind, placebo-controlled trial with 48 healthy Caucasian women with fine hair (average age 43.3 years), 10 mg/d of silicon as
ch-OSA for nine months improved hair tensile strength including elasticity and
break load and resulted in thicker hair.*[3]

In a 12-month clinical trial conducted at St. Thomas’ Hospital in London, women already taking 1000 mg of calcium and 800 IU of vitamin D, to which they added ch-OSA, saw thighbone mineral density at the hip (i.e., femoral
neck) increase by 2.00% compared to placebo. This was as a result of an increase in actual bone formation, not just a decrease in loss.[4] Furthermore, the procollagen marker P1NP (procollagen type-1 N-terminal propeptide)
increased significantly after 12 months in women who took ch-OSA compared to women in the placebo group. P1NP is known as the most sensitive marker for bone collagen formation and an early marker of bone formation.[4] Animal studies support the human clinical findings for ch-OSA with respect to collagen formation and bone mineral density.*[9-11]

In an open clinical study, 18 subjects were given five drops of ch-OSA twice daily for six months. Hair growth and hair loss assessments were performed using a semi-quantitative rating scale, and scores were analyzed using the
Friedman test. At the end of the six months, 94% of respondents had improved hair growth with 58% in the categories of moderate to marked hair growth. All respondents noted improvement in the body and texture of their hair.*[12]

Biotin
Biotin, as an essential component of carboxylase enzymes, has diverse roles in maintaining health. While overt biotin deficiency is known to result in skin irritation and hair loss, anecdotal evidence suggests that biotin supplementation supports healthy hair growth, and supplementing with biotin is a common method for enhancing skin health and hair and nail strength. Studies testing theeffects of biotin on nail health suggest that biotin supplementation improves nail thickness and reduces splitting.[13-15] In one study, 91% of subjects showed
definite improvement with firmer and harder finger nails after 5.5+/-2.3 months of 2.5 mg/d biotin.[16] Higher doses of biotin (9 mg to 16 mg/d) are used to support healthy lipid and glucose metabolism; and more recently, doses up
to 300 mg/d have been used to support muscle function related to neurologichealth.*[17,18]

RegeneMax® Plus Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving %Daily Value
Biotin 5000 mcg 16,667%
Choline (as choline-stabilized orthosilicic acid) 100 mg 18%
Silicon (as choline-stabilized orthosilicic acid) 5 mg **
** Daily Value not established.
Other Ingredients: HPMC (capsule), microcrystalline cellulose, and purified water.
Produced under US patents 5,922,360; 7,968,528; and 8,771,757.
ch-OSA and Advanced Collagen Generator are registered trademarks of Bio Minerals NV, Belgium.
MADE BY BIO MINERALS NV, BELGIUM
DIRECTIONS: Take one capsule two times per day, or as directed by your
healthcare practitioner.
Consult your healthcare practitioner prior to use. Individuals taking medication
should discuss potential interactions with their healthcare practitioner. Do not use
if tamper seal is damaged.
STORAGE: Store in a cool, dry place out of reach from children.
DOES NOT CONTAIN: Wheat, gluten, corn, yeast, soy, animal or dairy products,
fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically
modified organisms (GMOs), artificial colors, artificial sweeteners, or
preservatives.

How Much Do Xymogen Supplements Cost?

Xymogen is often a little pricier than normal supplements because its medical grade. The quality of supplements you get with Xymogen far exceeds OTC. By ordering through our site, you will receive Our Professional Discount which you can receive by using the link and ID and Name above.

Why Buy Xymogen Supplements?

According to Xymogen, Xymogen’s quality control department tests and verifies the identity, purity, potency, and composition of all raw materials when they come in, and all finished products before they leave the facility- this includes heavy metal testing for lead, mercury, arsenic, and cadmium on every single lot. You can be assured that you are getting the highest quality ingredients and the ingredients that are listed on the bottle and nothing else!

As an added safety measure, in instances where they suspect there is even the slightest possibility of contamination, they have the product tested, often by a third party independent laboratory, for a wide variety of potential contaminants (such as residual solvents, pesticides, PCB’s, gluten, citrinin, peak-X, etc), allowing Xymogen to stand behind their products.  The Quality Assurance Department oversees all of this processes-plus their manufacturing, production, packaging, labeling, and marketing operations-guaranteeing everything we do is in compliance.

References
1. Carlisle EM. Silicon as a trace nutrient. Sci Total Environ. 1988 Jul1;73(1-2):95-
106. [PMID: 3212453] 2. Barel A, Calomme M, Timchenko A, et al. Effect of oral intake of cholinestabilized orthosilicic acid on skin, nails and hair in women with photodamaged
skin. Arch Dermatol Res. 2005 Oct;297(4):147-153. [PMID: 16205932] 3. Wickett RR, Kossmann E, Barel A, et al. Effect of oral intake of choline-stabilized
orthosilicic acid on hair tensile strength and morphology in women with fine
hair. Arch Dermatol Res. 2007 Dec;299(10):499-505. [PMID: 17960402] 4. Spector TD, Calomme MR, Anderson SH, et al. Choline-stabilized orthosilicic
acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers
of bone formation in osteopenic females: a randomized, placebo-controlled trial.
BMC Musculoskelet Disord. 2008 Jun 11;9:85. [PMID: 18547426] 5. Viguet-Carrin S, Garnero P, Delmas PD. The role of collagen in bone strength.
Osteoporos Int. 2006;17:319-336. [PMID: 16341622] 6. Shuster S. Osteoporosis, a unitary hypothesis of collagen loss in skin and bone.
Med Hypotheses. 2005;65(3):426-432. [PMID: 15951132] 7. Calleja-Agius J, Muscat-Baron Y, Brincat MP. Skin ageing. Menopause Int. 2007
June;13(2):60-4. [PMID: 17540135] 8. Sumino H, Ichikawa S, Abe M, et al. (2004). Effects of aging and
postmenopausal hypoestrogenism on skin elasticity and bone mineral density in
Japanese women. Endocr J. 2004 Apr;51(2):159-164. [PMID: 15118265] 9. Calomme MR, Vanden Berghe DA. Supplementation of calves with stabilized
orthosilicic acid. Effect on the Si, Ca, Mg, and P concentrations in serum and
the collagen concentration in skin and cartilage. Biol Trace Elem Res. 1997
Feb;56(2):153-165. [PMID: 9164661] 10. Calomme MR, Wijnen P, Sindambiwe JB, et al. Effect of choline-stabilized
orthosilicic acid on bone density in chicks. Calcif Tissue Int. 2002, 70:292.
Poster presented at: 29th European Symposium on Calcified Tissues; May
25-29, 2002; Zagreb, Croatia. http://www.ectsoc.org/zagreb2002/poster3.htm.
Abstract P-139. Accessed December 16, 2015.
11. Calomme MR, Geusens P, Demeester N, et al. Partial prevention of long-term
femoral bone loss in aged ovariectomized rats supplemented with cholinestabilized orthosilicic acid. Calcif Tissue Int. 2006, Apr;78(4): 227-232. [PMID:
16604283] 12. Chan G. An open clinical study of the efficacy of choline-stabilized orthosilicic
acid in the management of hair loss. A pilot study. Paper presented at: 17th
Regional Conference of Dermatology; September 13-16, 2006; Bali, Indonesia.
13. Colombo VE, Gerber F, Bronhofer M, et al. Treatment of brittle fingernails and
onychoschizia with biotin: scanning electron microscopy. J Am Acad Dermatol.
1990 Dec;23(6 Pt 1):1127-32. [PMID: 2273113] 14. Hochman LG, Scher RK, Meyerson MS. Brittle nails: response to daily biotin
supplementation. Cutis. 1993 Apr;51(4):303-5. [PMID: 8477615] 15. Scheinfeld N, Dahdah MJ, Scher R. Vitamins and minerals: their role in nail
health and disease. J Drugs Dermatol. 2007 Aug;6(8):782-7. Review. [PMID:
17763607] 16. Floersheim GL. Treatment of brittle fingernails with biotin [in German]. Z Hautkr.
1989 Jan 15;64(1):41-8. [PMID: 2648686] 17. Sedel F, Bernard D, Mock DM, et al. Targeting demyelination and virtual
hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis.
Neuropharmacology. 2015 Sep 5. [Epub ahead of print] [PMID: 26327679] 18. Biotin: Monograph. Alt Med Rev. 2007;12(1):73-78. [on file] Additional references available upon request

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