Xymogen’s NeuroActives™ BrainSustain™

CLINICAL APPLICATIONS

» Supports Enhancement of Brain Function*
» Supports Brain Health and Healthy Memory*
» Provides Generous Antioxidant Support to the Brain*
» Supplies Micronutrients to Support Neuronal Energy Production*

According to Xymogen, NeuroActives™ BrainSustain™ represents more than 30 years of neuroscience research, this unique encapsulated formula is designed to enhance brain performance and promote brain health. A key component of a complete program to ensure optimal brain function, NeuroActives™ BrainSustain™ improves the energy production of brain mitochondria and provides generous antioxidant support to combat the damaging effects of excess free radicals in the brain.*

Available in 120 capsules & 240 capsules

  • To ORDER securely and directly from Xymogen:

  • Click on the following link.  https://www.wholescripts.com/register/lifespark
  • Use referral code “Lifespark” and practitioner name “Horvath” to set up your account for the lifesparknutrition.com discount.
  •  Allow a confirmation email from Wholescripts.
  • Save your login info and order whenever you want.

Discussion

NeuroActives™ BrainSustain™ by Xymogen provides an array of micronutrients and antioxidants that are essential to the structure, metabolism, and function of the brain and nervous system. This neurosupportive formula provides a foundational approach to sustaining neurological activity and integrity.*

N-Acetyl-Cysteine (NAC) As a source of the conditionally essential amino acid cysteine, NAC is a precursor to one of the brain’s most important antioxidants—glutathione. NAC itself is an effective antioxidant and has been shown to reduce the formation of free radicals that can contribute to oxidative damage in the brain.*[1]

Phosphatidylserine A phospholipid that is highly concentrated in the brain, phosphatidylserine (PS) plays a key role in neuronal energy production and communication. Since very little PS is found in food, we must synthesize or supplement the amount we need for optimal brain health. Improvements in cognitive function and memory have been observed following supplementation with PS.[2-4] For some individuals, cognitive decline may be related to “age-related decline in nutrition,”[5] and early nutrition intervention may be warranted. NeuroActives BrainSustain™ contains safe-source PS from sunflower lecithin and contains no animal products.*

Acetyl-L-Carnitine (ALCAR) The ALCAR form of the amino acid L-carnitine is found to have multifaceted roles in neuroprotection.[6] It is able to cross the blood-brain barrier where it stabilizes cell membranes, acts as an effective antioxidant, and protects brain cells from toxic chemicals and stress-induced damage.[7-9] In addition, ALCAR enhances neuronal energy production, facilitates transport of fuel and waste products into and out of mitochondria, and supports production of acetylcholine, a neurotransmitter essential to the processes of learning and concentration.*[8-10]

Alpha-Lipoic Acid Acting as both a fat- and water-soluble antioxidant, alpha-lipoic acid provides intracellular and extracellular
protection against oxidative stress. With its low molecular weight, alpha-lipoic acid is easily absorbed in the gastrointestinal tract. It then enters circulation, crosses the blood-brain barrier, and reaches the brain where it can regenerate other important antioxidants, including glutathione, vitamin E, and vitamin C.*[11,12]

Coenzyme Q10 (CoQ10) As a ubiquinone, CoQ10 facilitates the transfer of electrons in the electron transport chain (ETC), playing a crucial role in the formation of ATP (adenosine triphosphate) and the generation of energy within the cell. CoQ10 also donates electrons, making it an effective antioxidant. As such, CoQ10 protects cells,
cell membranes, and tissues from damaging free radicals and prooxidants. The antioxidant activity of CoQ10 may protect the brain from the oxidative stress that is believed to be partially responsible for the degeneration of neuronal cells.*[13]

Broccoli Seed Extract The patented form of the phytochemical in broccoli called sulforaphane glucosinolate (SGS™) is a key ingredient in NeuroActives BrainSustain. Extensive research demonstrates that when SGS is broken down to sulforaphane (its active form), it safely and effectively upregulates the Nrf2 system, enhances antioxidant production, and activates vital phase II detoxification enzymes.[14,15] This process provides protection from common toxins and xenobiotics.*

Adequate antioxidant protection from ongoing free radical damage is crucial to maintaining the health and function of the cell and, hence, tissues and organs, especially the brain. Unbridled oxidative damage can lead to metabolic disruption and organ dysfunction over time. Antioxidant-promoting phytochemicals such as SGS are considered “lifespan essentials” because they assist in maintaining health throughout adult life.*[16]

  • To ORDER NeuroActives™ BrainSustain™securely and directly from Xymogen:

  • Click on the following link.  https://www.wholescripts.com/register/lifespark
  • Use referral code “Lifespark” and practitioner name “Horvath” to set up your account for the lifesparknutrition.com discount.
  •  Allow a confirmation email from Wholescripts.
  • Save your login info and order whenever you want.

Supplement Facts

Serving Size: 4 Capsules
Servings Per Container:

AMOUNT PER SERVING % DAILY VALUE

Acetyl-L-Carnitine (as acetyl-L-carnitine HCl)

400 mg **

N-Acetyl-Cysteine

150 mg **

Phosphatidylserine (Sharp•PS®)

100 mg **

Alpha Lipoic Acid

100 mg **

Coenzyme Q10 (as ubiquinone)

100 mg **

Glucoraphanin (from broccoli extract)(Brassica oleracea italica)(seed)(TrueBroc®)

15 mg **

Other Ingredients: Tricalcium phosphate, HPMC (capsule), stearic acid, magnesium stearate, silica, and
calcium silicate.

Xymogen’s NeuroActives™ BrainSustain™Product Overview

Directions:

Take two to four capsules daily, or as directed by your healthcare practitioner.

Consult your healthcare practitioner prior to use. Individuals taking medication, especially cancer treatment, should discuss potential interactions with their healthcare practitioner.

Storage

Keep closed in a cool, dry place out of reach of children.

Does Not Contain

Wheat, gluten, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Other Ingredients

Tricalcium phosphate, HPMC (capsule), stearic acid, magnesium stearate, silica, and calcium silicate.

Trademarks

TrueBroc® is protected by trademarks and patents of Brassica Protection Products LLC: www.brassica.com/ip

Sharp•PS® is a registered trademark of Enzymotec Ltd.

  • To ORDER securely and directly from Xymogen:

  • Click on the following link. Set up your Xymogen account on Wholescripts. Allow a confirmation email from Wholescripts.  https://www.wholescripts.com/register/lifespark
  • Use referral code “Lifespark” and practitioner name “Horvath” to set up your account for the lifesparknutrition.com discount.
  • Save your login info and order whenever you want.
  • If you need help figuring out which supplements are best suited for your body, please go to www.lifesparknutrition.com click “SHOP” and click on “Medical Grade Supplement Program with Consult.”

In addition to using a supplement like NueroActives also Eat Nutrient-Dense, Whole Foods to Support Cognitive Performance

In contrast to the Standard American Diet, a diet composed of nutrient-dense, whole foods supports optimal cognitive function.

A recent study conducted at the University of Illinois looked at patterns of nutrient biomarkers in the blood of healthy adults to examine the association between nutrition and cognition. The researchers found that study participants with patterns of nutrient biomarkers associated with a plant-rich, whole-foods diet demonstrated better “network efficiency,” a subjective measure of cognition, and better performance on cognitive function tests compared to those with nutrient biomarker patterns indicative of an unhealthy diet. (11)

Find a Macronutrient Ratio That Works for You

Rebalancing macronutrients can also benefit cognitive performance. For some individuals, a high-fat ketogenic diet significantly enhances cognitive function. These anecdotal reports are supported by research demonstrating that a ketogenic diet improves memory and mild cognitive impairment. (1213Conversely, if you’ve been low carb or keto for a while and have noticed a decline in your memory, focus, or mood, it may be time to add more carbs to your diet. Nutrient-dense carbohydrates provide the brain with glucose for energy production and can help boost critical thinking, learning, and memory capacities.

Whatever macronutrient ratio you choose, the most important thing is to eat a diet that keeps your blood sugar stable. Frequent blood sugar swings are a risk factor for cognitive impairment, but they can be well managed through diet. (14)

Eight Superfoods for Your Brain to Optimize Cognitive Performance:

Once you’ve determined the macronutrient intakes that work best for your brain, it’s time to get down to the details and add specific foods and micronutrients that optimize cognitive performance.

1. Berries

Eating berries has been found to improve cognition in children, boost episodic and working memory in adults, and prevent cognitive decline. (151617These brain-boosting benefits are attributed to berries’ polyphenol content. In humans, polyphenols cross the blood–brain barrier and accumulate in brain regions important for learning and memory; once in the brain, these polyphenols may combat oxidative stress and neuroinflammation. However, berries also benefit brain health by promoting the growth of gut microbes with neuroprotective properties. (18) Try a mix of berries—blueberries seem to lead the pack for brain benefits—as well as sweet cherries, which have lots of polyphenols.

2. Dietary Fiber

Simply increasing the amount of fiber in your diet may boost your cognitive function. Prebiotic fiber, a type of dietary fiber fermented for fuel by beneficial gut bacteria, also boosts cognition. (19) In animal and human trials, eating prebiotic fiber improves synaptic plasticity, learning, memory, and executive functioning. (2021) Prebiotic fiber appears to positively impact cognition by elevating neurotrophic factors such as BDNF, modulating the gut–brain axis, and regulating blood glucose levels and insulin sensitivity. (222324)

Prebiotic fiber is found in:

  • Onions
  • Leeks
  • Garlic
  • Asparagus
  • Bananas
  • Chicory root
  • Jerusalem artichoke
  • Oats

3. Green Leafy Vegetables

Eat your greens” is advice you should take to heart if you want to boost your cognitive performance! Research indicates that nutrients in green leafy vegetables such as folate, phylloquinone, and lutein protect against cognitive impairment by reducing oxidative stress and neuroinflammation and enhancing mitochondrial function. (25) Aim for at least one serving per day of dark leafy greens such as spinach, Swiss chard, collard greens, and lettuce.

4. Nuts

Numerous studies demonstrate a relationship between nut intake and cognitive function. A high nut intake has been linked to better cognition in old age and strengthens brainwave functions associated with learning and memory. (2627) Nuts may boost cognition by improving insulin sensitivity and endothelial function, two important mediators of brain function, and by reducing inflammation. Walnuts in particular have been the focus of some of this research because they are especially high in the essential fatty acid alpha-linolenic acid (ALA), which is positively associated with brain function.

To reap the brain benefits of nuts, you don’t need to eat very much; a recent study found that eating just one handful of walnuts per day had a significant neuroprotective, memory-boosting effect. (28)

5. Dark Chocolate

Chocolate lovers, rejoice! We know from research that cocoa flavonoids enhance human cognition, making dark chocolate one food you’ll want to include in your diet. (29) The consumption of flavanol-rich cocoa improves cognitive performance in both older adults with memory impairment and those who are cognitively intact. It also improves processing speed, executive function, working memory, and verbal fluency. (30) Cocoa flavonoids boost cognitive performance by increasing BDNF, enhancing cerebrovascular blood flow, and improving insulin sensitivity. (31) You can get the benefits of dark chocolate by eating about one to two ounces per day. Note that chocolate should have a cocoa content of at least 70 to 75 percent to be considered dark. Be aware that “Dutch processing,” done to improve flavor, can also lower flavonoid content; choose “non-alkalized” or “natural” dark chocolate for maximum flavanols.

6. Eggs

For years, health authorities advised people to avoid eating whole eggs if they wanted to preserve their brain health. This misguided recommendation was based on the false premise that dietary cholesterol, which is abundant in eggs, raises blood cholesterol and the risk of chronic diseases such as heart disease and dementia. However, the diet–lipid hypothesis has since been disproven, and new research indicates that eggs are actually beneficial for brain health!

Eating eggs early in life improves biomarkers of infant brain development. (32) In adults, egg intake is associated with better performance on cognitive tests. (33) Pasture raised organic, non-gmo Eggs support optimal cognitive function by supplying the brain with choline and DHA, two crucial brain-supportive nutrients that I will discuss in more detail shortly. Eggs also contain the carotenoid lutein, which evidence suggests plays a vital role in neurological development. (34)

7. Coffee

Millions of people around the world rely on coffee to keep themselves energetic, focused, and productive throughout the day. Coffee’s primary ingredient, caffeine, dramatically enhances cognitive performance. (35) Caffeine enhances hippocampal neurotransmission and memory consolidation, making it a powerful tool for optimizing cognitive performance. (3637) However, decaffeinated coffee also increases alertness, suggesting that coffee has cognition-enhancing activity beyond its caffeine content.

8. Tea

If you’re not a coffee drinker, then consider adding tea to your brain-boosting diet plan. Drinking green and black tea, which both come from the Camellia sinensis plant, is inversely associated with cognitive dysfunction. (3839)

Some of the compounds in tea that may be responsible for its cognitive benefits include theanine and caffeine. (40) The caffeine in tea improves alertness and performance on long-duration cognitive tasks, while theanine promotes relaxation and calmness, creating a balanced state of focus for tackling cognitively demanding tasks.

  • To ORDER NeuroActives™ BrainSustain™ securely and directly from Xymogen:

  • Click on the following link. Set up your Xymogen account on Wholescripts. Allow a confirmation email from Wholescripts.  https://www.wholescripts.com/register/lifespark
  • Use referral code “Lifespark” and practitioner name “Horvath” to set up your account for the lifesparknutrition.com discount.
  • Save your login info and order whenever you want.
  • If you need help figuring out which supplements are best suited for your body, please go to www.lifesparknutrition.com click “SHOP” and click on “Medical Grade Supplement Program with Consult.”

References for NueroActives
1. Sansone RA, Sansone LA. Getting a knack for NAC: N-acetyl-cysteine. Innov Clin
Neurosci. 2011 Jan;8(1):10-4. [PMID: 21311702] 2. Kato-Kataoka A, Sakai M, Ebina R, et al. Soybean-derived phosphatidylserine
improves memory function of the elderly Japanese subjects with memory
complaints. J Clin Biochem Nutr. 2010 Nov;47(3):246-55. [PMID: 21103034] 3. Richter Y, Herzog Y, Cohen T, et al. The effect of phosphatidylserine-containing
omega-3 fatty acids on memory abilities in subjects with subjective memory
complaints: a pilot study. Clin Interv Aging. 2010 Nov 2;5:313-6. [PMID:
21103402] 4. Vakhapova V, Cohen T, Richter Y, et al. Phosphatidylserine containing omega-3
fatty acids may improve memory abilities in non-demented elderly with
memory complaints: a double-blind placebo-controlled trial. Dement Geriatr
Cogn Disord. 2010;29(5):467-74. [PMID: 20523044] 5. Suchy J, Chan A, Shea TB. Dietary supplementation with a combination of
alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic
acid, and phosphatidylserine reduces oxidative damage to murine brain and
improves cognitive performance. Nutr Res. 2009 Jan;29(1):70-4. [PMID:
19185780] 6. Picconi B, Barone I, Pisani A, et al. Acetyl-L-carnitine protects striatal
neurons against in vitro ischemia: the role of endogenous acetylcholine.
Neuropharmacology. 2006 Jun;50(8):917-23. [PMID: 16500685] 7. Steffen V, Santiago M, de la Cruz CP, et al. Effect of intraventricular injection of
1-methyl-4-phenylpyridinium: protection by acetyl-L-carnitine. Hum Exp Toxicol.
1995 Nov;14(11):865-71. [PMID: 8588946] 8. Sorbi S, Forleo P, Fani C, et al. Double-blind, crossover, placebo-controlled
clinical trial with L-acetylcarnitine in patients with degenerative cerebellar
ataxia. Clin Neuropharmacol. 2000 Mar-Apr;23(2):114-8. [PMID: 10803803] 9. Jones LL, McDonald DA, Borum PR. Acylcarnitines: role in brain. Prog Lipid Res.
2010 Jan;49(1):61-75. Review. [PMID: 19720082] 10. Kobayashi S, Iwamoto M, Kon K, et al. Acetyl-L-carnitine improves aged brain
function. Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S99-106. [PMID: 20590847] 11. Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant
alpha-lipoic acid. Free Radic Biol Med. 1997;22(1-2):359-78. Review. [PMID:
8958163] 12. Liu J. The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid
on improving age-associated mitochondrial and cognitive dysfunction: an
overview. Neurochem Res. 2008 Jan;33(1):194-203. Review. [PMID: 17605107] 13. Mancuso M, Orsucci D, Volpi L, et al. Coenzyme Q10 in neuromuscular and
neurodegenerative disorders. Curr Drug Targets. 2010 Jan;11(1):111-21.
Review. [PMID: 20017723] 14. Ping Z, Liu W, Kang Z, et al. Sulforaphane protects brains against hypoxicischemic injury through induction of Nrf2-dependent phase 2 enzyme. Brain
Res. 2010 Jul 9;1343:178-85. [PMID: 20417626] 15. Vauzour D, Buonfiglio M, Corona G, et al. Sulforaphane protects cortical neurons
against 5-S-cysteinyl-dopamine-induced toxicity through the activation of
ERK1/2, Nrf-2 and the upregulation of detoxification enzymes. Mol Nutr Food
Res. 2010 Apr;54(4):532-42. [PMID: 20166144] 16. Holst B, Williamson G. Nutrients and phytochemicals: from bioavailability to
bioefficacy beyond antioxidants. Curr Opin Biotechnol. 2008 Apr;19(2):73-82.

 

 

 

 

 

 

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